Publications

Wolfson, R.L. (2025). Spinal sensory innervation of the intestine. Curr Opin Neurobiol 90, 102973. 10.1016/j.conb.2025.102973.

Wolfson, R.L., Abdelaziz, A., Rankin, G., Kushner, S., Qi, L., Mazor, O., Choi, S., Sharma, N., and Ginty, D.D. (2023). DRG afferents that mediate physiologic and pathologic mechanosensation from the distal colon. Cell 186, 3368-3385 e3318. 10.1016/j.cell.2023.07.007.

Choi, S., Hachisuka, J., Brett, M.A., Magee, A.R., Omori, Y., Iqbal, N.U., Zhang, D., DeLisle, M.M., Wolfson, R.L., Bai, L., et al. (2020). Parallel ascending spinal pathways for affective touch and pain. Nature 587, 258-263. 10.1038/s41586-020-2860-1.

Hwang, W.L., Wolfson, R.L., Niemierko, A., Marcus, K.J., DuBois, S.G., and Haas-Kogan, D. (2019). Clinical Impact of Tumor Mutational Burden in Neuroblastoma. J Natl Cancer Inst 111, 695-699. 10.1093/jnci/djy157.

Yuskaitis, C.J., Jones, B.M., Wolfson, R.L., Super, C.E., Dhamne, S.C., Rotenberg, A., Sabatini, D.M., Sahin, M., and Poduri, A. (2018). A mouse model of DEPDC5-related epilepsy: Neuronal loss of Depdc5 causes dysplastic and ectopic neurons, increased mTOR signaling, and seizure susceptibility. Neurobiol Dis 111, 91-101. 10.1016/j.nbd.2017.12.010.

Wyant, G.A., Abu-Remaileh, M., Wolfson, R.L., Chen, W.W., Freinkman, E., Danai, L.V., Vander Heiden, M.G., and Sabatini, D.M. (2017). mTORC1 Activator SLC38A9 Is Required to Efflux Essential Amino Acids from Lysosomes and Use Protein as a Nutrient. Cell 171, 642-654 e612. 10.1016/j.cell.2017.09.046.

Wolfson, R.L., and Sabatini, D.M. (2017). The Dawn of the Age of Amino Acid Sensors for the mTORC1 Pathway. Cell Metab 26, 301-309. 10.1016/j.cmet.2017.07.001.

Wolfson, R.L., Chantranupong, L., Wyant, G.A., Gu, X., Orozco, J.M., Shen, K., Condon, K.J., Petri, S., Kedir, J., Scaria, S.M., et al. (2017). KICSTOR recruits GATOR1 to the lysosome and is necessary for nutrients to regulate mTORC1. Nature 543, 438-442. 10.1038/nature21423.

Okosun, J., Wolfson, R.L., Wang, J., Araf, S., Wilkins, L., Castellano, B.M., Escudero-Ibarz, L., Al Seraihi, A.F., Richter, J., Bernhart, S.H., et al. (2016). Recurrent mTORC1-activating RRAGC mutations in follicular lymphoma. Nat Genet 48, 183-188. 10.1038/ng.3473.

Saxton, R.A., Knockenhauer, K.E., Wolfson, R.L., Chantranupong, L., Pacold, M.E., Wang, T., Schwartz, T.U., and Sabatini, D.M. (2016). Structural basis for leucine sensing by the Sestrin2-mTORC1 pathway. Science 351, 53-58. 10.1126/science.aad2087.

Wolfson, R.L., Chantranupong, L., Saxton, R.A., Shen, K., Scaria, S.M., Cantor, J.R., and Sabatini, D.M. (2016). Sestrin2 is a leucine sensor for the mTORC1 pathway. Science 351, 43-48. 10.1126/science.aab2674.

Chantranupong, L., Wolfson, R.L., and Sabatini, D.M. (2015). Nutrient-sensing mechanisms across evolution. Cell 161, 67-83. 10.1016/j.cell.2015.02.041.

Wang, S., Tsun, Z.Y., Wolfson, R.L., Shen, K., Wyant, G.A., Plovanich, M.E., Yuan, E.D., Jones, T.D., Chantranupong, L., Comb, W., et al. (2015). Metabolism. Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1. Science 347, 188-194. 10.1126/science.1257132.

Chantranupong, L., Wolfson, R.L., Orozco, J.M., Saxton, R.A., Scaria, S.M., Bar-Peled, L., Spooner, E., Isasa, M., Gygi, S.P., and Sabatini, D.M. (2014). The Sestrins interact with GATOR2 to negatively regulate the amino-acid-sensing pathway upstream of mTORC1. Cell Rep 9, 1-8. 10.1016/j.celrep.2014.09.014.

Efeyan, A., Zoncu, R., Chang, S., Gumper, I., Snitkin, H., Wolfson, R.L., Kirak, O., Sabatini, D.D., and Sabatini, D.M. (2013). Regulation of mTORC1 by the Rag GTPases is necessary for neonatal autophagy and survival. Nature 493, 679-683. 10.1038/nature11745.